{"product_id":"origin-peptides-mots-c-10mg","title":"Origin Peptides MOTS-c 10mg Vial","description":"\u003cp\u003eMOTS-c, also written MOTS c or MOT-c, is a 16 amino acid peptide encoded not in the cell nucleus but in the mitochondrial genome, and it is the best studied member of the small family known as mitochondrial-derived peptides. This vial contains 10mg of lyophilised MOTS-c from Origin Peptides, batch numbered and independently tested. Supplied for laboratory research only and not for human consumption.\u003c\/p\u003e \u003ch2\u003eProduct specification\u003c\/h2\u003e \u003ctable\u003e \u003ctbody\u003e \u003ctr\u003e\n\u003cth\u003eProduct\u003c\/th\u003e\n\u003ctd\u003eMOTS-c (mitochondrial open reading frame of the 12S rRNA type-c)\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eCAS number\u003c\/th\u003e\n\u003ctd\u003e1627580-64-6\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eSequence\u003c\/th\u003e\n\u003ctd\u003eMRWQEMGYIFYPRKLR, 16 amino acids\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eMolecular formula\u003c\/th\u003e\n\u003ctd\u003eC101H152N28O22S2\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eMolecular weight\u003c\/th\u003e\n\u003ctd\u003e2174.6 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eForm\u003c\/th\u003e\n\u003ctd\u003eLyophilised (freeze-dried) powder in a sealed glass vial\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003ePer vial\u003c\/th\u003e\n\u003ctd\u003e10mg\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eBrand\u003c\/th\u003e\n\u003ctd\u003eOrigin Peptides\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eTesting\u003c\/th\u003e\n\u003ctd\u003eEvery batch independently tested for identity and purity; certificate of analysis published on the \u003ca href=\"\/pages\/lab-results\"\u003eLab Testing\u003c\/a\u003e page against the batch number printed on the vial\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eStorage\u003c\/th\u003e\n\u003ctd\u003eRefrigerate at 2 to 8C on arrival, protected from light; -20C for longer storage\u003c\/td\u003e\n\u003c\/tr\u003e \u003ctr\u003e\n\u003cth\u003eResearch use only\u003c\/th\u003e\n\u003ctd\u003eYes. Not for human or veterinary use\u003c\/td\u003e\n\u003c\/tr\u003e \u003c\/tbody\u003e \u003c\/table\u003e \u003ch2\u003eWhat the research says about MOTS-c\u003c\/h2\u003e \u003cp\u003eMOTS-c was described by Lee and colleagues at the University of Southern California in Cell Metabolism in 2015. The team found a short open reading frame inside the mitochondrial 12S rRNA gene, showed that it produced a peptide, and reported that the peptide acted on the folate cycle and AMPK signalling, mostly in skeletal muscle, in cell culture and in mice fed a high fat diet. It was one of the first demonstrations that mitochondria send peptide signals out to the rest of the cell, rather than only receiving them.\u003c\/p\u003e \u003cp\u003eFollow up work has extended the picture. Kim and colleagues reported in Cell Metabolism in 2018 that MOTS-c moves into the nucleus under metabolic stress and influences gene expression there. Reynolds and colleagues published in Nature Communications in 2021 that circulating and muscle MOTS-c levels rise with exercise in humans, and that giving it to older mice was associated with better physical capacity. Other groups have measured MOTS-c levels in people of different ages and metabolic states.\u003c\/p\u003e \u003cp\u003eThe human evidence is early and almost entirely observational: it measures how much MOTS-c people have, not what happens when it is given. An analogue, CB4211, entered early clinical testing but has not reported definitive results. MOTS-c is therefore best seen as a fast moving research compound for mitochondrial signalling and metabolic regulation, with strong preclinical interest and no established human outcome data.\u003c\/p\u003e \u003ch2\u003eQuality and testing\u003c\/h2\u003e\n\u003cp\u003eOrigin Peptides vials are filled to a stated milligram content, lyophilised and sealed, with the batch number printed on every vial. Every batch is independently tested for identity and purity before release, and its certificate of analysis is published on the \u003ca href=\"\/pages\/lab-results\"\u003eLab Testing\u003c\/a\u003e page so the report can be matched to the number on your vial. If you need the batch report for research records, contact sales@sarmsstore.co.uk with your batch number.\u003c\/p\u003e\n\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e \u003cp\u003e\u003cstrong\u003eIs MOTS-c legal in the UK in 2026?\u003c\/strong\u003e MOTS-c is not a controlled substance under the Misuse of Drugs Act 1971, so buying and possessing it as a research chemical is lawful in the United Kingdom in 2026. What is not lawful is selling or advertising it for human use, because the MHRA treats a product presented that way as an unlicensed medicine. That is why this listing, and every listing on this site, is worded for laboratory research and nothing else.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eHow does MOTS-c differ from SS-31?\u003c\/strong\u003e Both are studied in the context of mitochondria, but they work in opposite directions. MOTS-c is produced by the mitochondria and signals outwards to the cell. \u003ca href=\"\/products\/origin-peptides-ss-31-10mg\"\u003eSS-31\u003c\/a\u003e (elamipretide) is a synthetic tetrapeptide that travels to the inner mitochondrial membrane and binds cardiolipin. Researchers interested in cellular energy metabolism also look at \u003ca href=\"\/products\/origin-peptides-nad-plus-500mg\"\u003eNAD+\u003c\/a\u003e and \u003ca href=\"\/products\/origin-peptides-5-amino-1mq-10mg\"\u003e5-Amino-1MQ\u003c\/a\u003e; the \u003ca href=\"\/blogs\/news\/ss-31-research-guide\"\u003eSS-31 research guide\u003c\/a\u003e compares the evidence.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eHow should the vial be stored?\u003c\/strong\u003e Lyophilised MOTS-c is stable in transit. Store the sealed vial at 2 to 8C away from light on arrival, or at -20C for longer storage. Reconstitution with a sterile diluent such as \u003ca href=\"\/products\/origin-peptides-bacteriostatic-water-10ml\"\u003eOrigin Peptides bacteriostatic water\u003c\/a\u003e is a laboratory step and no usage guidance is given on this site.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eHow fast is delivery?\u003c\/strong\u003e We despatch UK orders the same working day when placed before the cut off, by tracked delivery that usually arrives in two to three working days, with next day delivery available at checkout. Parcels are discreet and carry no compound name. International shipping covers most countries except those on the restricted list at checkout.\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eIs MOTS-c prohibited in sport?\u003c\/strong\u003e MOTS-c is not approved for therapeutic use anywhere, which places it under section S0 of the WADA Prohibited List, non-approved substances, prohibited at all times. Its reported action on AMPK signalling is also relevant to the metabolic modulators section. Anyone subject to anti-doping rules should treat it as prohibited.\u003c\/p\u003e \u003cp\u003e\u003cem\u003eResearch use only. This product is supplied strictly for laboratory and research purposes and is not for human or veterinary use. It is not a medicine, it is not a food supplement, and it is not intended to diagnose, treat, cure or prevent any disease. Sold to persons aged 18 or over only.\u003c\/em\u003e\u003c\/p\u003e ","brand":"Origin Peptides","offers":[{"title":"Default Title","offer_id":58802691473789,"sku":"ORG-MOTSC10MG","price":49.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0505\/7033\/0306\/files\/origin_mots-c_10-mg-01.png?v=1790977913","url":"https:\/\/sarmsstore.co.uk\/products\/origin-peptides-mots-c-10mg","provider":"SARMs Store","version":"1.0","type":"link"}