What Exactly is Ibutamoren / Nutrobal (MK-677)?
Ibutamoren, also known as Nutrobal and MK-677, is a selective agonist of the ghrelin receptor and growth hormone secretagogue. It has become one of the most admired Selective Androgen Receptor Modulators (SARMs) for bodybuilders. This compound is highly effective in increasing insulin-like growth factor 1 (IGF-1) and secretion of growth hormone.
Nutrobal was originally developed to treat health conditions such as osteoporosis, muscle wasting, and obesity. This orally administered growth hormone secretagogue is also indicated for the treatment of elderly patients with hip fractures.
Action Mechanism of Nutrobal: How Does it Work?
Nutrobal works by improving the release of growth hormone-releasing hormone (GHRH). As its name suggests, this is not growth hormone (GH) but another hormone that releases it...simple enough?
Nutrobal also inhibits the signalling of the somatostatin receptor. In addition to this, it amplifies the signalling of GHRH in somatotrophs of the anterior pituitary gland. Nutrobal is instrumental in minimising the release of somatostatin, a substance that turns off the release of growth hormone in the body.
Research shows that Nutrobal, or Ibutamoren, has the ability to improve the level of growth hormones in the body. It does this by mimicking the action of ghrelin, a hormone that promotes hunger and stimulates metabolism.
MK-677 binds to GHSR, one of the androgen receptors in the brain. It is worthwhile to note that activated GHSR stimulates the release of growth hormone from the brain.
By doing this, Nutrobal also improves a number of factors, including:
- Biological rhythms;
- Pleasure and sense of wellbeing.
One of the bonuses of Nutrobal is that it improves the levels of growth hormones with little to no increase in the levels of other hormones like cortisol.
Other possible advantages can include: improved complexion, increased energy levels and strength, increased endurance, protein synthesis, and nitrogen retention.
Nitrogen is a fundamental component of amino acids, which are responsible for the formation of protein. When the body is in a positive nitrogen balance, it has the material to repair injuries and produce the required levels of hormones.
Several studies have also suggested that MK-677 stimulates an increased immune system response.
One more noteworthy characteristic of MK-677 is that it does not at all compete with the levels of growth hormone that are usually associated with the administration of exogenously administered human growth hormone. This means that you can make use of Nutrobal for HGH cycles, offering an increase of natural GH pulses. It also means that you don’t have to deal with painful or annoying daily human growth hormone injections.
As all these advantages suggest, Nutrobal can be used by athletes, bodybuilders, and others for a wide range of purposes under medical approval. From growing muscle mass to getting shredded, there’s a whole range of benefits.
Benefits of Ibutamoren (MK-677)
1. Improves Muscle Building
Nutrobal (MK-677) is extremely effective in increasing lean body mass.
It is also equally effective in increasing muscle strength and mass and minimising body fat.
2. Reduces Muscle Wasting
As well as building existing muscle, Nutrobal has the unique potential of reversing diet-induced weight loss that can result in muscle wasting. Those looking to lose weight without taking on a fitness regimen will likely find that they lose muscle as well as body fat.
Not only this, MK-677 can even improve muscle strength, gait speed, and minimise the number of falls in elderly patients with hip fractures.
3. Improves Bone Density
Growth hormone is highly effective in increasing bone turnover and eventually density of the bones.
In a study of older women with existing osteoporosis, Emily Krantz, MD, reported that: “Years after treatment stopped, women who were treated with growth hormone still experienced improved bone density and reduced fracture risk.”
4. Improves Quality of Sleep
Ibutamoren has the ability to improve rapid eye movement (REM) sleep duration and overall sleep quality. REM sleep is the light sleep where you dream.
Light sleep may not sound good, but REM is highly important for memory and stimulates the areas of the brain which promote learning when you are awake.
Interestingly, metabolic activity is also on a high during this period of sleep - so there may be direct physical connections between the amount of light sleep you get and your progress in the gym.
Adults should spend about 20-25% of their overall sleep time in REM.
5. Enhances Longevity
We can’t pretend that this is the key to living forever… However, MK-677 has coined the nickname “the fountain of youth” among its most satisfied users. It is a well-known fact that muscle mass and secretion of growth hormone (GH) decline from mid-puberty throughout the remainder of human life.
As we know, this results in reduced physical fitness and a general decline in bodily health as we age. However, Nutrobal can restore growth hormone and IGF-1 levels to optimum levels.
6. Nootropic Effects
Athletes can often find themselves in a cycle where stress results in sleep loss, which leads to energy loss and “brain fog”. This in turn affects workouts, both through a lack of motivation and the body not operating at its peak endurance levels. Each factor affects the other, which means it can be difficult to break the cycle and snap back into a healthy regimen.
Nootropics are a type of substance that can boost brain performance and activity. They can contribute to advanced concentration, memory, and motivation.
Nutrobal is often used as a nootropic since it acts in the ghrelin receptor (which is known to have nootropic effects). The increases in IGF-1 are linked to improvements in learning and memory.
Moreover, Nutrobal can improve sleep quality and sleep duration; both of these are essential for enhanced cognitive functioning.
7. Treating Growth Hormone Deficiency
As we already know, Nutrobal demonstrates great efficacy when it comes to improving the levels of growth hormone (GH), IGF-1, and IGFBP-3 (the main carrier of IGF-1 through the body).
This is a breakthrough for the treatment of growth hormone deficiencies, since it essentially replenishes what the body is lacking. Growth hormone deficiency (GHD), also known as dwarfism, may be present at birth or may happen as a result of events during or just after birth. GHD may also be acquired later in life and even in adulthood.
Research into the long-term effects of Nutrobal is still in its early days, but its effects in the short term are hugely promising. With medical intervention, the effects of growth hormone deficiency can be paused and treated.
The best thing is that these elevated effects can be experienced without causing any change in the concentrations of thyroxine (T4), thyrotropin, prolactin, glucose, triiodothyronine (T3), insulin, and cortisol.
8. Improving Wound Healing and Tissue Regeneration
Nutrobal aids in wound healing and tissue generation. The largest of all benefits associated with Nutrobal is its outstanding ability to heal tendons, bones, and ligaments. It also heals up old injuries and tightens loose skin.
9. Improves Shredding
A lot of potential MK-677 users are worried about how a product that increases ghrelin (the “hunger hormone”) can help when they want to stay in a calorie deficit.
An underrated powerhouse, ghrelin boosts hunger and helps you consume more calories. At the same time, it plays a critical role in the regulation of energy use (stored fat).
When chosen safely and in line with your doctor’s advice, there is nothing wrong with adding other compounds to combat these effects and help you limit hunger cravings. Read our post on stacking to learn more about safely combining supplements for multiple effects.
However, Nutrobal’s muscle-building properties do help you retain your hard-earned gains, even on a calorie deficit.
10. Body Recomp and Post-Cycle Therapy
Nutrobal is ideal if you are looking for a product that can recompose the body. In addition to this, MK-677 is also effective for anyone who is on testosterone replacement therapy after the age of 40 or cruising on anabolic steroids.
Nutrobal is equally effective during post-cycle therapy (PCT), used to restore the levels of growth hormone and IGF-1 after an anabolic steroid cycle.
How to Use Ibutamoren?
Ideally, Ibutamoren is best used once in the morning and once in the evening, since it has a half-life of 24 hours. For men, an optimum dosage is somewhere in the range of 12.5mg (25mg per day total).
Women should consider a much lower dosage, sometimes up to half the recommended amount for men. However, several hormonal and life-related factors should be considered and can affect each individual greatly. It is never safe just to guess!
However, it is not uncommon for advanced athletes and bodybuilders to use Ibutamoren in daily dosages of 50-75mg every day. Please note that this is up to three times the suggested rate and the dosage that is right for you should always be discussed with and validated by your doctor.
The suggested Ibutamoren cycle is 8-12 weeks for men, and again should be significantly shorter for women. During a bulking stack, many users consider 10mg of RAD-140 (Testolone) alongside the two split dosages. Again, this should be discussed prior to usage and stacking should not be attempted by those new to taking supplements.
For cutting cycles, Nutrobal can be stacked at two split dosages (12.5mg) with 20mg of GW-5015216 (Cardarine) every day in a cycle of 6-10 weeks (all quantities for men). It may also be stacked in dosages of 25mg every day along with Testosterone Enanthate 150mg a week and Primobolan 500mg a week, in a cycle of 8-12 weeks.
You need to note that dosages of Nutrobal, just like other drugs, should never be increased indiscriminately else this can attract side effects. Results take time, and impatience can cost you in the long run.
Nutrobal should not be used by pregnant or breastfeeding women, or by those who think they may be pregnant. It is also contraindicated to children below the age of 21 years, or those hypersensitive to its active or inactive ingredients.
Furthermore, it is highly recommended that you seek medical advice before using this Selective Androgen Receptor Modulator. A little precaution and safety ahead of anything is never a bad thing, and starting with Nutrobal is no exception.
Why Use MK-677 Instead of Peptides?
The biggest reasons why you should consider MK-677 instead of peptides to improve growth hormone levels are storage, mixing, and injecting factors. You can store MK-677 for years without worrying about it getting rancid. It can be quickly taken as an oral product and there are no injections involved. Moreover, most peptide companies these days are selling bunk or underdosed products.
According to industry estimates, almost 90 percent of the peptides sold on the Internet come straight from China. Buyers often have no idea what exactly they contain or how rigorous the safety processes are. As a result, they have a reputation for being completely worthless, to say the least.
It’s never advisable to buy SARMs if you don’t know exactly where they are coming from and what they contain. On the other hand, you get research-grade and premium-quality products when you buy from SARMs Store. Don’t risk the alternative!
Where to Buy MK-677?
SARMs Store is the best place on the internet to buy MK-677. This way, you will always be assured that you will receive the most top-class, research-grade Nutrobal at astonishing prices.
It is important to remember that the market for Selective Androgen Receptor Modulators can be a shady one, to say the least. This is because SARMs are banned by institutions like the World Anti-Doping Agency (WADA), the United States Anti-Doping Agency (USADA), and the United Kingdom Anti-Doping (UKAD) for almost all forms of amateur, competitive, and professional sports.
Therefore, you should exercise a high sense of care diligence: always do your research and consult with a professional for approval and advice. It is always best to trust the industry leader, and this is just one of the reasons why customers from all parts of the world admire SARMs Store.