SARMs For Hormone Replacement Therapy
In recent years, powerful demographic trends have demonstrated that scientists and researchers are dedicating their efforts heavily towards ageing of human populations.
As men and women grow older, their muscle strength, muscle mass, and leg power reduce due to the loss of skeletal muscle fibres, especially type II fibres. This in turn leads to an increased risk of fractures, falls, and disability. Previously, scientists used to suggest anabolic therapies but they are now rightly replaced by selective androgen receptor modulators (SARMs) that can attain the anabolic effects without the side effects.
One of the biggest advantages of selective androgen receptor modulatorsis they are potent orally-active preparations with a safe profile and good efficacy. These potent compounds have the ability to selectively target muscle tissues to stimulate judicious restoration of physiological functions that are usually regulated by endogenous androgens.
Recent advances clearly indicate that the concept of hormone replacement therapy is undergoing a fundamental change, both in the quantum of use and in the wide range of applications that may become the beneficiaries from these advances.
The development and marketing of novel selective androgen receptor modulators have the backing of both pre-clinical and clinical proofs of concepts that compounds can be developed with a great and improvised degree of tissue selectively. This is done with a predefined purpose to target the androgen receptors to eliminate side effects and maintain and enhance the protective and positive effects of selective transcriptional receptor activation.
Role of SARMs in Androgen Therapy for Men
Currently, androgenic formulations for replacement therapy are predominantly restricted to skin delivery or injectable formulations of testosterone or testosterone esters. However, injectable forms of testosterone esters (like testosterone cypionate or enanthate) produce undesirable and disturbing fluctuations in testosterone blood levels.
These compounds are associated with supraphysiological concentrations in the initial stages and subnormal levels towards the end of the duration prior to the next injection that provide a completely unsatisfactory profile and side effects in most cases. On the other hand, oral preparations such as 17α-methyltestosterone and fluoxymesterone are associated with liver toxicity. Similarly, skin patches lead to skin irritation and daily application dramatically minimises the acceptability and usefulness of this form of therapy.
Selective androgen receptor modulators target androgen receptors selectively in different tissues to elicit the desired activity. SARMs are orally active and characterised by a pharmacokinetic profile that is consistent with once a day administration. Moreover, they have the potential of stimulating seminal vesicles, prostate, and other reproductive organs at doses that are equipotent to those required to offer significant increases in muscle strength and mass. SARMs are also useful to promote fat-free mass, restore/maintain libido, and support bone growth.
The potential benefit of androgen therapyutilising selective androgen receptor modulators clearly expands well beyond primary or secondary hypogonadism and into areas including HIV wasting and cancer cachexia, glucocorticoid-induced osteoporosis, osteopenia and osteoporosis in elderly men, anaemia, male contraception, different forms of muscular dystrophies, and many other types of disorders.
Medical studies have demonstrated that SARMs like a dose of 3mg daily of MK-2866 (Ostarine) administered to elderly men resulted in an increase in muscle mass by 1.4kg (3.5lbs) within a period of three months. Moreover, the use of Ostarine is associated with an increase in stair climb output by 25 percent and speed by 15 percent. Moreover, the use of MK-2866 is associated with dramatic increases in the quality of life and the sense of well-being. Buy Ostarinenow the world’s most preferred SARMs Store.