The History And Present Of SARMs-Evolution Of SARMs
Performance enhancing drugs have always impressed and evoked the attention of mankind. From the Ancient Romans to the Greeks, the use of performance-enhancing substances such as animal testicles and herbs was widespread and well-known to the world at large. With passing times, these substances were replaced by anabolic compounds and prohormones that helped athletes and bodybuilders broke plateaus and gain a distinctive edge over natural athletes. However, there were huge risks with the use of these compounds and the risks are far too great than the benefits.
This was just one of the reasons why anabolic compounds were banned by sports bodies and world governments because of the severe side effects associated with them. These are the times when the world of bodybuilding and athletics were looking for a safer alternative and came Selective androgen receptor modulators(SARMs).
Selective androgen receptor modulators came to prominence after the side effects of compounds like steroids were highlighted by different medical studies and research. Anabolic steroids that were previously prescribed on a routine basis had to be replaced with safer and potent alternatives. Consumers were searching for safer and advanced muscle-building agents that could be easily and discreetly purchased on the internet instead of dealing with shady characters in the locker rooms.
The discovery and popularity of SARMs into the scientific community was undoubtedly a milestone to both anti-ageing and medical organisations. The most common concern with androgen therapy was the scarce availability of safe and potent compounds to administer without the side effects that are caused by the exogenous administration of natural androgens.
The primary objective of most SARM researchers was to gain knowledge and insights about agonists of the androgen receptor without the possibility of it attaching to and serving as the aromatase and 5a-reductase substrates. With passing time, pharmaceutical companies and researchers managed to develop primarily after it became apparent that chemical modifications to bicalutamide, the anti-androgen, forged androgens with agonistic activity. Soon, different classes of Selective androgen receptor modulators were identified and synthesised.
Big pharmaceutical companies were behind these innovations to treat severe health conditions and not for the bodybuilding industry. For instance, they wanted to develop drugs for preventing muscle wasting in patients suffering from cancer and HIV/AIDS.
How Do SARMs Actually Work?
Muscle tissues go on a deteriorating spree with passing age because of the breakdown and the subsequent loss of the type 2 muscle fibres. This muscle fibre type is critical for power, endurance, and general functional fitness and a decline of it can pose a threat to the smooth and normal functioning of daily activities.
Several studies have demonstrated that training and workouts like resistance training can help in stimulating an increase and preserve type 2 muscle fibre. The levels of strength and lean muscle mass can be boosted in individuals with androgen deficiency by adding Selective androgen receptor modulators into the mix.
Selective androgen receptor modulators work in the body through:
- Resistance to aromatase that facilitates the conversion of testosterone into estrogen.
- Demonstrating special affinity with muscle and bone tissue but not the liver, kidney, prostate, and heart tissues.
- Not breaking down into waste molecules that could have otherwise resulted in steroid-like side effects.
- Not suppressing the natural production of hormones like testosterone.
In addition to these advantages, selective androgen receptor modulators don't negatively impact or put a strain on the body organs. They don't severely or permanently shut down Hypothalamus-Pituitary-Testes-Axis (HPTA). The best thing is that the use of SARMs unlike that of anabolic androgenic steroids don't result in side effects such as breast tissue development in men, oily skin, acne, prostate damage, shrinking of the testicle in males, deepening of the voice and abnormal menstrual cycles in females, and growth of hair on the face, stomach, and upper back.
Moreover, medically-guided use of research-grade and genuine SARMs for medicinal and legal purposes in strict accordance with medical instructions don't cause side effects such as increased aggression, hair loss, reproductive damage, or prostate problems.
Variability In Selective Androgen Receptor Modulators
One of the biggest differences between Selective androgen receptor modulatorsand compounds like anabolic steroids is the variability in structure among them. It is worth noting that any compound that has the potential of binding to the androgen receptor of the body and gets activated in specific tissue can be termed as a Selective androgen receptor modulator.
Essentially, this means that there is little to no structural justification behind the naming as compared to that of anabolic androgenic steroids (4-ring base).
Selectivity Is The Key
A Selective androgen receptor modulator to be considered useful medically must demonstrate favourable tissue selectivity. In other words, it should demonstrate agonist activity in bone and muscle while displaying very little or no interaction with secondary sex tissues such as the prostate and seminal vesicles.
It can be said that a good Selective androgen receptor modulator is one that selectively stimulates the growth of muscles but leaves the prostate, liver, hairline, and breasts alone. Furthermore, the SARM must ideally possess anabolic activity similar or more on the lines of Testosterone.
Current Status Of SARMs On The WADA Prohibited List
Since 2008, Selective androgen receptor modulators have been prohibited by the World Anti-Doping Agency (WADA). This is for the simple reason that SARMs are potent drugs with a wide range of distinctive advantages that can give a great "unfair" edge to an athlete over the competition. Currently, Selective androgen receptor modulators are prohibited at-all-times in the category of “other anabolic agents” under Section S1.2 of the WADA Prohibited List. This means that you must completely avoid using SARMs or very carefully use them if you are a tested athlete as the presence of Selective androgen receptor modulatorsin your samples can land you in deep trouble.
Present Day Popularity Status Of SARMs
Today, Selective Androgen Receptor Modulators are treated as an exceptional class of molecules that have the ability to treat mild to severe health conditions such as osteoporosis, muscle wasting, and androgen deficiency.
Athletes and bodybuilders are making the use of SARMs to lose fat, improve bone density, and gain extra muscles while staying away from the dreaded side effects of drugs such as anabolic androgenic steroids. Not only this, Selective Androgen Receptor Modulators are highly effective to treat the loss of libido, infertility, and the feelings of depression, tiredness, low confidence, and poor esteem while improving overall health and the sense of well-being.
In addition to these advantages, SARMs are globally admired for their high bioavailability. This unique advantage makes them worthwhile candidates for effective consumption and absorption.
Currently, more and more bodybuilders are using the capsulated form of right and obvious reasons. This form of Selective Androgen Receptor Modulators has countless advantages:
- Capsulated SARMsare easier to ship.
- They have a longer shelf life than liquid SARMs.
- Capsulated SARMs are more appealing to the end users (as sharing of needles is avoided, chances of sexually-transmitted diseases are eliminated, and the possibility of pain or swelling at the injection sites is eliminated).
- Some SARM ingredients lose strength and efficacy in liquid form.
- Ingredients in liquid SARMs are predisposed for a merger with the digested food and getting out of the body quickly. On the other hand, capsulated SARMs are designed with a predefined purpose to allow the body to absorb and retain the positive activities of the beneficial SARM ingredients.
- Capsulated SARMsdon't have unnecessary fillers like artificial flavours and additives.
No wonder, the world of bodybuilding is going crazy over these safe and potent fitness supplements that have already revolutionised the world of weightlifting and intense workouts. However, it is very important for you to always ensure that Selective androgen receptor modulators should always be purchased only from a legitimate SARMs Storethat deals in genuine and research-grade selective androgen receptor modulators. The online SARMs Store must offer safe and secure payment options and the option to discreetly pack and ship the products after educating you fully about these drugs so that you always make an informed decision.
Moreover, the use of these extremely potent drugs should always be made in complete accordance with medical instructions and for medicinal and legitimate purposes. The dosages of SARMs should never be increased and these drugs should never be abused in hopes of quick pursuits as the abuse of any drug can lead to side effects and selective androgen receptor modulators are no exceptions. Selective androgen receptor modulators are potent drugs that must always be used responsibly.