Are you looking to build lean muscle and strong bones? Are you hoping to improve your athletic performance and combat ageing?
Have you already implemented changes to your diet and exercise programmes? If so, you’ve likely seen results. However, you might be hungry for more, and MK-677 might be the "something more" you need.
Read on to learn more about MK-677 and the ways it can benefit your body, mind, and overall health.
What Is MK-677?
MK-677, or Ibutamoren, is a selective androgen receptor modulator (SARM). SARMs offer benefits similar to steroids without the associated negative side effects.
MK-677 produces its benefits by increasing levels of IGF-1 and growth hormone in the body.
The pituitary gland naturally produces growth hormone. This hormone promotes cell reproduction and regeneration.
Growth hormone is responsible for normal childhood development. It is also responsible for building, maintaining, and repairing tissue throughout a person’s life. Finally, growth hormone regulates metabolism and body composition.
Bodybuilders and other athletes seek precisely these benefits. Therefore, they aim to increase levels of growth hormone. Unfortunately, as the body ages, however, levels of growth hormone naturally fall.
Many bodybuilders turn to MK-677 to reverse these declines and their associated effects.
What Are the Symptoms of Growth Hormone Deficiency?
When growth hormone levels fall, the body exhibits several changes. These changes can be significant.
The effects of low growth hormone levels can include:
- Increased fat stores
- Muscle wasting
- Weaker bones
- Sagging skin and other effects of decreasing skin elasticity
- Decreased energy and endurance
- Decreased kidney function
- A weakened immune system
- Increased "bad" LDL cholesterol levels
- Sexual dysfunction
- Difficulty with memory and focus
- Psychological dysfunction, including greater feelings of isolation and increased difficulty dealing with negative emotions
If you notice these symptoms, MK-677 therapy may help to reverse them.
How Does MK-677 Work?
MK-677 increases levels of growth hormone that are responsible for the above functions.
To produce growth hormone, the pituitary gland and hypothalamus must be activated. To utilise growth hormone, in turn, hormone receptors need to be activated.
Secretagogues are responsible for activating hormone production. Meanwhile, agonists are responsible for activating hormone receptors.
Secretagogues are substances that cause other substances to be produced. The naturally occurring hormone ghrelin is a growth hormone secretagogue. Ghrelin prompts the pituitary gland and hypothalamus to produce growth hormone.
MK-677 mimics this action, making it a potentially powerful growth hormone secretagogue (GHS).
MK-677 also increases growth hormone levels by increasing the effectiveness of the body's ghrelin supply. As a ghrelin agonist, MK-677 activates ghrelin receptors. Ghrelin, once again, stimulates the production of growth hormone.
What Are the Benefits of MK-677?
Especially when used in conjunction with diet and exercise, MK-677 offers a host of benefits. Many of these benefits reverse the effects associated with low growth hormone levels.
Increased Muscle Mass
By increasing levels of IGF-1 and growth hormone, MK-677 can build muscle mass and strength.
MK-677 users can anticipate adding up to 5-10kg of lean muscle. Of course, results will vary depending on a person's current health status. However, studies show the benefits of MK-677 on muscle size and strength for diverse groups. In a study of 60-year-olds, researchers found that increasing growth hormone levels increased muscle strength.
In addition to health and age, diet and exercise programmes also affect results. MK-677 produces the best results as a component of an overall nutrition and workout programme.
Decreased Fat Stores
Obese individuals may be at particular risk for growth hormone deficiencies. Low levels of growth hormone, in turn, mean that these individuals struggle to burn fat and build lean muscle. They are also at increased risk of chronic conditions, including cardiovascular disease.
Research shows that treatment with MK-677 can significantly increase levels of IGF-1 and growth hormone. Participants in one study saw IGF-1 levels rise by up to 40%. As IGF-1 and growth hormone levels increased, participants also exhibited increases in their basal metabolic rate. Perhaps most importantly, participants' showed a sustained increase in fat-free mass.
These results suggest that MK-677 not only builds muscle. It can also improve overall body composition.
Increased Bone Strength
Bone strength is a concern for all populations. However, building and maintaining bone density can be a particular concern for bodybuilders and other groups. In addition to bodybuilders, women, older people, and people who are obese may need to pay close attention to bone strength.
MK-677 shows promise in promoting bone health in each of these groups.
Studies show that MK-677 enhances the body's bone-building efforts among elderly subjects. After receiving a daily oral dose of MK-677, subjects had significantly higher levels of osteocalcin. Osteocalcin is a protein hormone necessary for bone formation.
Post-menopausal women experienced similar benefits when taking MK-677. In this study, female subjects took a daily dose of MK-677. As a result, their growth hormone levels rose. Increasing growth hormone levels, in turn, led to increased bone density.
Researchers suggest that these effects occurred as growth hormones stimulated osteoblasts. Osteoblasts are the cells responsible for forming new bone.
Finally, a study of obese but otherwise healthy men confirmed the beneficial effects MK-677 on male subjects as well.
MK-677 provides the greatest benefits when it is integrated into a nutrition and workout regimen. Fortunately, MK-677 can make sticking with a workout regimen easier.
Studies show that GHSs, like MK-677, can improve subjects' ability to tolerate intense workouts. Further improving endurance, higher growth hormone levels are also associated with improved oxygen intake.
The body's efforts to grow and replace worn-out cells require adequate sleep. It's no surprise, then, that increased growth hormone levels are associated with improved sleep.
Studies show that MK-677 can promote deep REM sleep and improve sleep quality. These effects hold even among older individuals who, prior to treatment, had experienced sleep disturbances.
Improved Skin Health
As a person ages and growth hormone levels fall, skin elasticity also decreases. Increasing growth hormone levels can reverse these effects.
A study of 60-year-old men showed that increasing growth hormone levels increased skin thickness by 7.1%.
By increasing growth hormone levels, MK-677 can promote skin health.
The body's levels of growth hormone naturally fall as a person ages. Many of the effects of ageing come as these levels fall.
Growth hormone is responsible for cell reproduction and regeneration. As long as the body continues to produce new cells to replace old, worn-out cells, the body functions properly. When the body's efforts to replace worn-out cells lag, a person feels tired and achy. Furthermore, body systems no longer function optimally.
GHSs, like ghrelin, increase growth hormone levels and can, thus, counter these effects. One study administered ghrelin orally to elderly male and female subjects. Researchers found that ghrelin raised elderly participants' IGF-1 and growth hormone levels to those of young adults.
By mimicking the effects of ghrelin, MK-677 may produce similar benefits.
Improved Cognitive Function
MK-677 increases the effectiveness of the body's natural supply of ghrelin. Often described as the "hunger hormone," ghrelin stimulates appetite. As discussed above, ghrelin also stimulates the production of growth hormone.
However, more recent studies suggest that ghrelin may also stimulate brain cell growth and regeneration. Many people report being able to think more clearly on an empty stomach. Scientists believe that ghrelin may be responsible for this mental clarity.
One study injected ghrelin into mice. It found that these injections improved the rodents' memories. It also helped them learn new concepts better and faster.
By acting as a ghrelin agonist, MK-677 may offer similar benefits among humans. In short, MK-677 may keep both your body and your brain young.
Improved Psychological Well-Being
Lower levels of growth hormone are associated with decreased psychological well-being. Treatments that increase growth hormone levels show the potential to improve the quality of life in these individuals.
After treatment to increase growth hormone levels, adult subjects reported improved mood and energy levels.
By increasing growth hormone levels, MK-677 can improve psychological well-being.
What Are the Side Effects of MK-677?
An advantage of MK-677 and other SARMs is their ability to produce steroid-like benefits without the associated side effects.
Steroid use is associated with significant health risks. This is because steroids bind not only to hormone receptors in muscles and bones. Steroids also bind to receptors in the brain, eyes, and skin. In doing so, steroids produce a host of negative effects.
Because they only bind to muscle and bone receptors, MK-677 and other SARMs offer a much safer alternative.
Side effects from MK-677 are mild and most often result when users exceed the recommended dosage. They can include:
- Excessive appetite
- Joint pain
- Increased insulin resistance
The potential of MK-677 to increase insulin resistance can be problematic for individuals who are diabetic. People who exhibit increased insulin sensitivity may also find their symptoms worsen when taking MK-677. These individuals should consult a doctor before starting on an MK-677 regimen or any supplement.
Does MK-677 Cause Headaches?
Some users report more frequent headaches when taking MK-677. However, among the side effects associated with MK-677, headache is not listed. What explains the omission?
In fact, MK-677 does not cause headaches. Studies have repeatedly failed to find a link between MK-677 use and headaches.
As with other potential side effects, users are only likely to experience headaches when they take MK-677 improperly.
Experts suggest water retention as one explanation for the headaches some MK-677 users report. Taken at high doses, MK-677 can cause the body to retain fluids. This is especially true among individuals who do not drink enough water.
When the body retains fluid for extended periods of time, blood pressure can increase. Increased blood pressure can cause headaches.
If you take the recommended dose and drink plenty of water, you can rest assured that MK-677 is not causing your headaches.
How Can I Incorporate MK-677 Into My Health Regimen?
Ibutamoren MK-677 is orally active. This means that you can take it by mouth as a pill.
The recommended dose varies across genders and among individuals.
Most men experience benefits with a daily dose of 5-25 milligrams/day. The recommended dose for women ranges from 5-15 milligrams/day.
MK-677 has a 24-hour half-life. This means that it takes up to 24-hours after dosing for levels of MK-677 to fall by half. Therefore, users can take a single daily dose. However, MK-677 levels peak four to six hours after dosing. Thus, experts recommend taking a split dose of MK-677.
Ideal times for dosing are approximately 30-40 minutes before a workout and after meals.
For both men and women, MK-677 provides the most benefits when taken in cycles. The optimal MK-677 cycle ranges from 8 to 14 weeks for men and 6-8 weeks for women.
Still, many users take MK-677 indefinitely.
Stacking MK-677 and Other SARMs
Stacking refers to the practice of combining supplements. Combining MK-677 with other SARMs can allow these compounds to work together. By combining the effects of multiple SARMs, users can see better and faster results.
The best SARMs to stack with MK-677 include Ostarine, Andarine S-4, and Cardarine. Stacking these SARMs in cycles of 8-12 weeks tends to produce the greatest benefits.
Bodybuilders can include MK-677 in cutting and bulking cycles. Stacking MK-677 with Ligandrol LGD-4033 is ideal for promoting muscle mass gains. Stacking MK-677 with Andarine S-4 and GW-501516 can promote fat loss.
Stacking MK-677 with Cardarine GW-501516 can also improve endurance.
How Long Will It Take To See Results?
MK-677 works quickly to increase levels of IGF-1 and growth hormone. Shortly after ingestion, these levels increase dramatically. Users often report seeing benefits within a week.
Building a Healthy Body and Mind with MK-677
Bodybuilders and others concerned with muscle strength and body composition can benefit from MK-677. The benefits of MK-677 extend beyond the physical, however. They include increased cognitive function and improve psychological well-being.
Combining MK-677 supplements with an overall diet and workout regimen maximises these benefits.
As you design your health plan, count on SARMs Store for all of your needs. We are a trusted SARMs UK distributor. Check out our other blog posts to learn more or start shopping today.