Yohimbine
Yohimbine, an alpha-2 adrenergic receptor antagonist, is one of the most popular ingredients in pre-workout, fat-burner, and dietary supplements. Yohimbine supplements are used for a wide range of purposes, including but not limited to stimulating weight loss and treating erectile dysfunction (ED). Yohimbine is equally effective to treat sexual problems that are a result of depression medications called selective-serotonin reuptake inhibitors (SSRIs). It is also used by athletes and bodybuilders to improve performance and Yohimbine is also known to reduce fear related to certain phobias.
Action Mechanism Of Yohimbine
Yohimbine inhibits alpha-1 and alpha-2 adrenoceptors, reduces serotonin levels, and increases the levels of dopamine and adrenaline. It is also known to reduce blood sugar levels, release insulin, and increase blood pressure. It leads to dilation of genital blood vessels and new impulse transmission to genital tissue. Yohimbine is also known to enhance reflex excitability in the sacral region of the spinal cord. It is all well-known for its serotonin receptor blocking, calcium channel blocking, and monoamine oxidase inhibiting effects.
Yohimbine inhibits presynaptic alpha-2 adrenergic receptors much on the lines of Reserpine though its action is for a shorter duration and weaker. The peripheral autonomic nervous system effect of Yohimbine is to reduce sympathetic (adrenergic) and increase parasympathetic (cholinergic) activity. It is worthwhile to remember here that erection in male sexual performance is associated with cholinergic activity and to alpha-2 adrenergic blockade that may theoretically lead to reduced or increased penile inflow, or both.
Getting rid of stubborn subcutaneous fat stores as your diet down is usually a difficult process because of a number of reasons. There is no wonder that most of us find have certain areas that are "stubborn" or don't easily give up ugly fat [usually lower abs, lower back, and the waist for men and the legs and hips for women]. More often than not, this is due to a high count of the Alpha-2 Receptors in the fat cells that tells the body to hold onto the fat in these areas for survival purposes. Yohimbine inhibits these Alpha-2 Receptors and thus kills the message to retain that stubborn fat. It also frees up the fat for oxidisation (burning).
Enzymatic Interactions
Yohimbine has the ability to interact with the CYP2D6 enzyme and inhibit its functioning. A study measuring Ki noted an apparent Ki of 0.52uM for purified CYP2D6 enzymes and 0.23uM for microsomes. This extends to Corynanthine with an apparent Ki of 0.08uM. It is worthwhile to note here that this is the same enzyme that metabolises Yohimbine into 11-hydroxy Yohimbine and demonstrates over a 1000-fold variation between individuals based on CYP2D6 expressed genotype (with little interaction with CYP3A4).
Benefits Of Yohimbine
- Yohimbine helps in relieving unwanted cravings.
- It helps to fight stubborn belly fat.
- Yohimbine reduces fat mass without negatively affecting lean mass that is critical for optimising body composition.
- It improves exercise performance by staving off physical fatigue that is a good thing simply because workout performance can be reduced due to calorie deficit.
- Yohimbine boosts metabolism for best fat-burning experiences.
- It dramatically improves endurance and energy levels.
- Yohimbine is second to none for burning stubborn arm, love handles, glutes (butt), and thigh fat.
- Yohimbine works great as an effective appetite suppressant.
- The amazingly powerful stimulant properties of Yohimbine make it a great choice for athletes, on and off the field.
- Not only this, Yohimbine significantly increases the subjective measurements of sexual satisfaction, desire, frequency of sexual encounters, and quality of erections during sexual intercourse.
- It also alleviates both physical and psychological symptoms that are generally associated with erectile dysfunction.
Adrenergic Neurotransmission
The most-researched and primary mechanism of Yohimbine is the inactivation (antagonism) of a class of receptors called as Alpha-2-Adrenergic receptors. Yohimbine inhibits these autoreceoptors on presynaptic noradrenergic neurons to increase the release of noradrenaline as the negative feedback inhibition loop gets disrupted.
Yohimbine And Fear Extinction
Yohimbine has a unique ability to facilitate fear extinction that is a psychological phenomenon where continuous exposures to a fearful stimulus generally leads to desensitization to the stimuli and reduced or eliminated fear associated with it. It is for this reason that Yohimbine is linked to improved fear extinction secondary to exposure therapy.
Yohimbine And Fat Loss
Yohimbine acts upon the adrenergic receptor system of fat cells that regulate thermogenesis. The beta-subunits of the adrenergic receptors, which are targets of ephedrine, are seen as fat loss stimulatory as they enhance the activity of Adenyl Cyclase (an enzyme) and subsequently Cyclic adenosine monophosphate [(a derivative of adenosine triphosphate (ATP)] levels.
It is worthwhile to remember here that the alpha-subunits are more suppressive of the process of fat metabolism. Yohimbine, being a selective alpha-2 adrenergic receptor antagonist (inactivator), inhibits the activation of the suppressive receptor sets and preserves the activity of Adenyl Cyclase and the mediated effects through the beta receptors.
How To Take Yohimbine?
Generally, Yohimbine is best used in daily dosages of 0.2 mg per kilogram of body weight to burn fat. This would mean a dosage of 14mg for a 150lb individual or 18 mg for q 200lb individual. It is important to note here that Yohimbine supplementation is most effective during short-term fasting or between meals. If you have any doubts or confusion regarding the ideal Yohimbine dosage, it is always better to have a word with your nearest doctor or pharmacy instead of taking wrong Yohimbine dosages.
Ideally, Yohimbine is best administered before fasted cardio. Insulin blunts the effects of Yohimbine on the Alpha-2 Receptors. Therefore, eating close to using Yohimbine would be of no benefit and it is always a good point to fast for at least 3-4 hours before making the use of Yohimbine. Secondly, fat is required to be burnt after the Alpha-2 Receptors have been blocked. This means that the body should be performing some form of activity and there is surely no better activity than fasted cardio.
Stacking Yohimbine
Yohimbine can be stacked with Selective androgen receptor modulators like Ostarine(MK-2866), Ibutamoren(MK-677), Andarine(S-4), LGD-4033, and Cardarine(GW-501516).
The stack of GW-501516 and Yohimbine is exceptional in more than just a way. Cardarine is ideal to getting deeper into prep workouts and improving endurance. It is equally effective to eliminate the feeling of getting drained during intense workouts because of high amounts of cardio and low carbs. In other words, Cardarine helps you do more reps with heavy weights in better ways. If that is not all, it switches the preferred energy source of the body from glucose (carbohydrates) to fats that means you will burn out more fat throughout the day. This will also mean that there will be more of stored glycogen for future intense workouts. On the other hand, Yohimbine is definitely more pronounced than GW-501516.
Contraindication/Precautions
Yohimbine is contraindicated to individuals who have a medical history of or are presently struggling with health complications such as anxiety, depression, hypotension, angina, kidney disease, or liver disease. It is also not suggested to pregnant or lactating women and even children. The use of Yohimbine should be cautiously made if you are suffering from diabetes, schizophrenia, hypertension, or benign prostatic hyperplasia.
It is important to note that Yohimbine demonstrates additive effects with monoamine oxidase inhibitors. Yohimbine may reduce or increase blood pressure with tricyclic antidepressants.
The dosages of Yohimbine should not be increased or abused at any point of time in hopes of quick results. The abuse of Yohimbine can lead to side effects like itching, dizziness, and allergic reactions. The use of Yohimbine should always be followed by a prior consultation from a medical professional.
How To Buy Yohimbine?
If you are looking to buy Yohimbine, we recommend selecting only an eminent Yohimbine seller like theSARMs Store. This is simply because there are too many fake Yohimbine sellers out there and trusting them will mean you not only losing on your hard-earned money, but also exposing your body to fake, under-dosed, or sub-standards products.
For this, it is always recommended to read reviews, feedback, suggestions, and complaints (if any) from different reputed bodybuilding and supplement forums. This will help you identify the best sellers of Yohimbine and choose the best Yohimbine supplements to suit your specific bodybuilding, health, and fitness, requirements., Moreover, it will help you make an informed decision to stay protected against possible incidences of Yohimbine abuse. Remember, it is always better to stay protected and using Yohimbine for your supplement requirements is no exception.