The What And Why Of Yohimbine
In the last few years, Yohimbine has been the subject of many heated debates among industry insiders and fitness enthusiasts alike.
If you are looking for a performance enhancing drug that can help you gain muscle mass and lose fat while improving your performance in the bedroom, it is time that you read more about the wonder drug known as Yohimbine.
Yohimbine, an indole alkaloid derived from the bark of the Central African Yohimbe tree, is known for offering a wide range of benefits. It has a role as a dopamine receptor D2 antagonist, a serotonergic antagonist, and an alpha-adrenergic antagonist.
Pharmacology
Yohimbine can be best described as an indolalkylamine alkaloid with chemical similarity to reserpine. It has the potential of inhibiting presynaptic alpha-2 adrenergic receptors. The peripheral autonomic nervous system effect of Yohimbine is to reduce sympathetic (adrenergic) and increase parasympathetic (cholinergic) activity.
Yohimbine is also known to inhibit alpha-1 and alpha-2 adrenoceptors. By doing this, it stimulates an increase in adrenaline and dopamine and reduces serotonin levels. This, in turn, helps in the release of insulin and a reduction in blood sugar levels. The drug is also known to inhibit dopamine-2 and dopamine-3 (D2 and D3) receptors and serotonin-1B, -1D, -2A, and -2B (5-HT1B, 5-HT1D, 5-HT2A, and 5-HT2B) receptors.
It is worthwhile to note here that erection in male sexual performance is associated with cholinergic activity and to alpha-2 adrenergic blockade that theoretically lead to an increased or decreased (or both) penile inflow. Yohimbine exerts its positive effect on erectile ability by producing a significant increase in sympathetic drive secondary to a release in norepinephrine. It also has the ability to stimulate the rate of cells in noradrenergic nuclei of the brain.
Yohimbine And Fat Loss
Yohimbine is extremely popular with athletes and bodybuilders during SARM cutting cycles because of its potential as a weight loss drug.
Alpha-2 receptors are common in body sites that tend to accumulate fat preferentially: thighs, breasts, abdomen, and buttocks. Alpha-2 receptor sites when exposed to circulating catecholamines like epinephrine and norepinephrine inhibit the release of fatty acids (lipolysis) while the beta receptors stimulate lipolysis.
Essentially, the release of fatty acids from adipose tissue into the bloodstream is stimulated by glucagon, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine, and growth hormone. Fatty acids once in the bloodstream are generally quickly oxidised if the concentration of fatty acid blood is not elevated from fatty acid input that happens with a meal.
Usually, fatty acid blood concentration favours fat storage when it is high that results from inactivity and over-eating. Hypothetically speaking, the inhibition of alpha-2 receptors proves useful for freeing up the catecholamines such as norepinephrine during weight loss that makes it more available for stimulating beta receptor sites that result in a higher rate of lipolysis. Yohimbine through its alpha 2-adrenergic receptor antagonist activity increases norepinephrine levels in the bloodstream.
Medical Uses Of Yohimbine
Yohimbine is extremely effective when it comes to treating impotence. This is one of the biggest reasons why Yohimbine is routinely indicated as a sympatholytic and mydriatic to male patients with vascular or psychogenic and diabetic origins. Yohimbine is also indicated for treating general sexual problems in both men and women.
Use of Yohimbine supplements is also associated with dramatic improvements in the levels of weight loss, athletic performance, blood pressure, and flow of blood in the body. It is also used to treat a wide range of health complications including but not limited to insomnia, obesity, syncope, dementia, diabetic complications, and male impotence.
Yohimbine is also useful to treat dry mouth syndrome or Xerostomia, a health condition in which there is a decrease in the amount of saliva produced. It is worth noting here that saliva production is increased by Acetylcholine and is regulated by alpha-2-adrenoceptors. People who are diagnosed with xerostomia suffer from a lack of acetylcholine and Yohimbine helps them by increasing acetylcholine.
An often-overlooked advantage of Yohimbine is its unique ability to treat individuals with an overdose of Clonidine, which is a prescription medication used for treating Attention-deficit/hyperactivity disorder(ADHD), high blood pressure, high blood pressure, anxiety disorders, and withdrawal symptoms.
Yohimbine in a combination with Naloxone (a drug that treats opioid overdose) also demonstrates efficacy to treat Polycystic ovary syndrome that is a variety of symptoms that happen in women who have too high levels of male hormones (androgens).
Yohimbine Benefits For Athletes And Bodybuilders
Yohimbine is also known to reduce the fear that is associated with certain phobias. By doing this, it helps athletes and other sportsmen climb higher and faster and realise their otherwise-unexplored or previously-unattainable objectives.
One of the biggest advantages of Yohimbine when it comes to fat loss is its ability to reduce food intake and appetite. It is also useful to increase fat breakdown during fasting or before exercise. According to a study, daily Yohimbine supplementation has the ability to reduce body fat levels in athletes from 9.3 to 7.1 percent.
Best known for producing hyperadrenergic physiological effects, Yohimbine is best used for cutting cycles where the primary objective of those into athletics and bodybuilding to gain or improve muscle definition. Yohimbine is an excellent drug to get the toned and ripped look before a competition.
Many animal and human studies have demonstrated that Yohimbine is extremely effective to get rid of fear of certain things, people, or animals by increasing norepinephrine levels. This is exactly the reason why this drug is routinely prescribed to patients with social anxiety disorders and it helps them by reducing social anxiety and improving mood.
Not only this, Yohimbine is also useful to improve long-term memory by improving the levels of norepinephrine. This drug also demonstrates efficacy to control blood clotting by inhibiting alpha-2 adrenoceptors and facilitating the conversion of epinephrine to norepinephrine. These qualities make Yohimbine an excellent drug for sportsmen who are involved in complex games such as chess and other strategy games. Moreover, Yohimbine also improves the quality of life, self-esteem, and self-confidence by enhancing the sense of well-being.
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Recommended Dosage Of Yohimbine
The recommended dosage of Yohimbine for men is 25-50mg every day, divided into two equal sub-doses. This drug should be taken with meals and preferably 30-45 minutes before a workout session, in a cycle of eight to twelve weeks. For women, the recommended dosage of Yohimbine is 10-20mg every day, divided into two equal sub-doses. Women should ideally take this drug with meals and preferably 30-45 minutes before a workout session, in a cycle of eight to twelve weeks.
Yohimbine is also useful to treat anorgasmia (also known as orgasmic dysfunction). A study demonstrated that daily dosages of 20mg, with 5 mg escalations to a maximum of 50mg every day is ideal for the management of anorgasmia.
Yohimbine Cycle For Men
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Week |
Yohimbine |
|||
|
1 |
25mg every day |
20mg every day |
|
|
|
2 |
25mg every day |
20mg every day |
|
|
|
3 |
25mg every day |
20mg every day |
|
|
|
4 |
25mg every day |
20mg every day |
|
|
|
5 |
25mg every day |
20mg every day |
|
|
|
6 |
50mg every day |
20mg every day |
|
|
|
7 |
50mg every day |
20mg every day |
|
|
|
8 |
50mg every day |
20mg every day |
|
3 capsules a day |
|
9 |
50mg every day |
20mg every day |
|
3 capsules a day |
|
10 |
50mg every day |
20mg every day |
|
3 capsules a day |
|
11 |
50mg every day |
20mg every day |
|
3 capsules a day |
|
12 |
50mg every day |
20mg every day |
|
3 capsules a day |
|
13 |
|
|
3 capsules a day |
|
|
14 |
|
|
3 capsules a day |
|
|
15 |
|
|
3 capsules a day |
|
|
16 |
|
|
3 capsules a day |
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Tips And Precautions
Yohimbine is not recommended for children and women who are pregnant or breastfeeding. It should be used with great caution when taken alongside medicines for high blood pressure, phenothiazines, or tricyclic antidepressants. This compound is not recommended for individuals with psychiatric conditions and kidney problems.
Furthermore, a high sense of care and diligence should be observed when this drug is administered to individuals with a medical history of increased basal sympathetic outflow or those who are presently undergoing concurrent treatment with tricyclic antidepressants or similar drugs that may interfere with the metabolism of norepinephrine or neuronal uptake.
Yohimbine should never be abused as it is a potent compound. Yohimbine abuse can lead to side effects such as nausea, anxiety, dizziness, and headaches. The use of Yohimbine should not be made along with haemophiliacs and it should also not be used by those who have recently undergone surgery as it reduces clotting. Blood thinners like warfarin, aspirin, and heparin should not be taken alongside Yohimbine.