In stock
MOTS-c 10mg Vial
Multibuy saving applies across any products in your basket.Add a second bottle and pay £47.50 each.
Sold strictly for laboratory research. Not for human consumption. 18+ only.
Encapsulated and dispatched from our UK warehouseUK supplier
About MOTS-c
About MOTS-c
MOTS-c, also written MOTS c or MOT-c, is a 16 amino acid peptide encoded not in the cell nucleus but in the mitochondrial genome, and it is the best studied member of the small family known as mitochondrial-derived peptides. This vial contains 10mg of lyophilised MOTS-c from Origin Peptides, batch numbered and independently tested. Supplied for laboratory research only and not for human consumption.
Read the full research summaryHide the research summary
What the research says about MOTS-c
MOTS-c was described by Lee and colleagues at the University of Southern California in Cell Metabolism in 2015. The team found a short open reading frame inside the mitochondrial 12S rRNA gene, showed that it produced a peptide, and reported that the peptide acted on the folate cycle and AMPK signalling, mostly in skeletal muscle, in cell culture and in mice fed a high fat diet. It was one of the first demonstrations that mitochondria send peptide signals out to the rest of the cell, rather than only receiving them.
Follow up work has extended the picture. Kim and colleagues reported in Cell Metabolism in 2018 that MOTS-c moves into the nucleus under metabolic stress and influences gene expression there. Reynolds and colleagues published in Nature Communications in 2021 that circulating and muscle MOTS-c levels rise with exercise in humans, and that giving it to older mice was associated with better physical capacity. Other groups have measured MOTS-c levels in people of different ages and metabolic states.
The human evidence is early and almost entirely observational: it measures how much MOTS-c people have, not what happens when it is given. An analogue, CB4211, entered early clinical testing but has not reported definitive results. MOTS-c is therefore best seen as a fast moving research compound for mitochondrial signalling and metabolic regulation, with strong preclinical interest and no established human outcome data.
Lab testing
Origin Peptides vials are filled to a stated milligram content, lyophilised and sealed, with the batch number printed on every vial. Every batch is independently tested for identity and purity before release, and its certificate of analysis is published on the Lab Testing page so the report can be matched to the number on your vial. If you need the batch report for research records, contact sales@sarmsstore.co.uk with your batch number.
Specification
| Product | MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) |
|---|---|
| CAS number | 1627580-64-6 |
| Sequence | MRWQEMGYIFYPRKLR, 16 amino acids |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Form | Lyophilised (freeze-dried) powder in a sealed glass vial |
| Per vial | 10mg |
| Brand | Origin Peptides |
| Testing | Every batch independently tested for identity and purity; certificate of analysis published on the Lab Testing page against the batch number printed on the vial |
| Storage | Refrigerate at 2 to 8C on arrival, protected from light; -20C for longer storage |
| Research use only | Yes. Not for human or veterinary use |
Delivery and returns
Orders placed before 2pm Monday to Friday are dispatched the same day. Tracked UK delivery is free over £60 (£3.49 below), usually two to three working days, with a next day upgrade for £4.49 at checkout. Packaging is plain with no product names on the outside.
Unopened products can be returned within 30 days of delivery for a full refund, and faulty items within 14 days.
Questions
Is MOTS-c legal in the UK in 2026? MOTS-c is not a controlled substance under the Misuse of Drugs Act 1971, so buying and possessing it as a research chemical is lawful in the United Kingdom in 2026. What is not lawful is selling or advertising it for human use, because the MHRA treats a product presented that way as an unlicensed medicine. That is why this listing, and every listing on this site, is worded for laboratory research and nothing else.
How does MOTS-c differ from SS-31? Both are studied in the context of mitochondria, but they work in opposite directions. MOTS-c is produced by the mitochondria and signals outwards to the cell. SS-31 (elamipretide) is a synthetic tetrapeptide that travels to the inner mitochondrial membrane and binds cardiolipin. Researchers interested in cellular energy metabolism also look at NAD+ and 5-Amino-1MQ; the SS-31 research guide compares the evidence.
How should the vial be stored? Lyophilised MOTS-c is stable in transit. Store the sealed vial at 2 to 8C away from light on arrival, or at -20C for longer storage. Reconstitution with a sterile diluent such as Origin Peptides bacteriostatic water is a laboratory step and no usage guidance is given on this site.
How fast is delivery? We despatch UK orders the same working day when placed before the cut off, by tracked delivery that usually arrives in two to three working days, with next day delivery available at checkout. Parcels are discreet and carry no compound name. International shipping covers most countries except those on the restricted list at checkout.
Is MOTS-c prohibited in sport? MOTS-c is not approved for therapeutic use anywhere, which places it under section S0 of the WADA Prohibited List, non-approved substances, prohibited at all times. Its reported action on AMPK signalling is also relevant to the metabolic modulators section. Anyone subject to anti-doping rules should treat it as prohibited.
Research use only. This product is supplied strictly for laboratory and research purposes and is not for human or veterinary use. It is not a medicine, it is not a food supplement, and it is not intended to diagnose, treat, cure or prevent any disease. Sold to persons aged 18 or over only.
Pair it.
Add all four and save 10%
The research pairing for this compound, and the bacteriostatic water every lyophilised vial needs. Three items takes 10% off everything.
